Multicomponent Electrocatalytic Selective Approach to Unsymmetrical Spiro[furo[3,2-c]pyran-2,5′-pyrimidine] Scaffold under a Column Chromatography-Free Protocol at Room Temperature

Electrochemical synthesis suggested a mild, green and atom-efficient route to interesting useful molecules, thus avoiding harsh chemical oxidizing reducing agents used in traditional synthetic methods. Organic electrochemistry offers an excellent alternative conventional methods of organic creates modern tool for carrying out synthesis, including cascade multicomponent ones. In this research, novel electrocatalytic transformation was found: the electrochemical assembly arylaldehydes, N,N′-dimethylbarbituric acid 4-hydroxy-6-methyl-2H-pyran-2-one one pot reaction carried alcohols undivided cell presence alkali metal halides with selective formation substituted unsymmetrical 1′,3′,6-trimethyl-3-aryl-2′H,3H,4H-spiro[furo[3,2-c]pyran-2,5′-pyrimidine]-2′,4,4′,6′(1′H,3′H)-tetraones 73–82% yields. This new process is selective, facile efficient way obtain spiro[furo[3,2-c]pyran-2,5′-pyrimidines]. According screening molecular docking data using self-made Python script Flare, all synthesized compounds may be prominent different medical applications, such as breast cancer, neurodegenerative diseases treatments connected urinary tract, bones cardiovascular system.